Valproate use in men
Published on 5 Sep 2024 · source: MHRA — Medicines and Healthcare products Regulatory Agency
What this means
Drug Safety Update is the MHRA bulletin for healthcare professionals: new safety information, restrictions of use and recommendations for monitoring.
Summary
A retrospective observational study has indicated a possible association between valproate use by men around the time of conception and an increased risk of neurodevelopmental disorders in their children. Inform male patients who may father children of this possible increased risk and the recommendation to use effective contraception during valproate treatment and for at least 3 months after stopping valproate.